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DeCS
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Descritor Inglês:
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NFATC Transcription Factors
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Descritor Espanhol:
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Factores de Transcripción NFATC
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Descritor Português:
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Fatores de Transcrição NFATC
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Sinônimos Inglês:
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NFAT Transcription Factor 1
NFAT Transcription Factor 2
NFAT Transcription Factor 3
NFAT Transcription Factor 4
NFAT Transcription Factor 5
Nuclear Factors of Activated T-Cells
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Categoria:
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D12.776.930.608
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Definição Inglês:
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A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. |
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Nota Histórica Inglês:
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2006(1993)
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Qualificadores Permitidos Inglês:
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Número do Registro:
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51192
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Identificador Único:
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D050778
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Ocorrência na BVS:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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